The Long and Winding Road: Connecting Cortex to Cortex Through the Thalamus. (360G-Wellcome-213692_Z_18_Z)
Our current model of the thalamus as a modulator and transmitter of sensory information is difficult to reconcile with the connectivity and physiology of the high-order thalamic nuclei (HOn). The dominance of cortical over peripheral input, variety of cortical areas providing modulation and cell-to-cell diversity in cortical projection targets have made the HOn difficult to understand. I propose that inhibitory circuits are key to understanding the function of diverse HOn pathways since they're in a privileged position to potentially gate behaviourally-relevant pathways and shape the coupling of HOn neurons to cortical areas. I will combine wide-field imaging and extracellular recordings from LP, TRn and vLGn in behaving mice to determine the cortical network affiliation of diverse LP units, whether these networks change with behavioural context, and how inhibitory neurons coordinate activity between LP neurons affiliated with distinct cortical networks during behaviour. Next, I will bi-directionally disrupt inhibition in vLGn and TRn, studying how this affects cortical activity and behaviour and enquiring whether the two types of inhibition have different functions. Lastly, I will search for the circuit substrate of the inhibitory interactions between LP networks revealed in vivo by combining tracer injections and optogenetic circuit mapping in slices.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 300000 |
Applicant Surname | Marques-Smith |
Approval Committee | Basic Science Interview Committee |
Award Date | 2018-10-31T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 213692/Z/18/Z |
Lead Applicant | Dr Andre Marques-Smith |
Partnership Value | 300000 |
Planned Dates: End Date | 2020-04-10T00:00:00+00:00 |
Planned Dates: Start Date | 2019-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Dr Sonja Hofer |