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C. elegans – a model system to study causation in the microbiome-gut-brain axis (360G-Wellcome-213954_Z_18_Z)

<p>Metagenomic approaches are generating a long list of health and disease states associated with the microbiome (the microbes inhabiting our digestive tract) but without mechanistic understanding. <strong>The challenges arise from the enormous complexity of the microbiome, including genetic, environmental and dietary variations, microbe-microbe interactions, and the cost associated with studying the microbiome using murine models. If the field is to move beyond association, simple, well-controlled and cost-effective models allowing unbiased high-throughput studies are needed.</strong> The nematode <em>C. elegans</em> is a genetically tractable model, ideally suited for mechanistic and causative studies of host-microbiome and microbe-microbe interactions shaping host physiology and metabolism.</p> <p>&nbsp;</p> <p><u>Aims: </u></p> <p>1) Establish an experimental microbiome&nbsp;in <em>C. elegans</em> based on strains from the human microbiome associated with health, disease and ageing</p> <p>2) Generate fluorescent labelled bacterial strains and perform real-time imaging of gut colonisation</p> <p>3) Characterise the effects of the experimental microbiome on the microbiome-gut-brain axis during ageing</p> <p>&nbsp;</p> <p>The experimental microbiome in <em>C. elegans</em> will be an important contribution to the field, complementing existing models. It will allow me to establish important collaborations, form a basis for my future research and address one of the most important questions of modern biology: the effects of the microbiome on host physiology.</p>

£99,905

06 Sep 2018

Grant details
Amount Awarded 99905
Applicant Surname Ezcurra
Approval Committee Science Seeds Advisory Panel
Award Date 2018-09-06T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Seed Award in Science
Internal ID 213954/Z/18/Z
Lead Applicant Dr Marina Ezcurra
Planned Dates: End Date 2021-05-03T00:00:00+00:00
Planned Dates: Start Date 2019-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
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