C. elegans – a model system to study causation in the microbiome-gut-brain axis (360G-Wellcome-213954_Z_18_Z)
Metagenomic approaches are generating a long list of health and disease states associated with the microbiome (the microbes inhabiting our digestive tract) but without mechanistic understanding. The challenges arise from the enormous complexity of the microbiome, including genetic, environmental and dietary variations, microbe-microbe interactions, and the cost associated with studying the microbiome using murine models. If the field is to move beyond association, simple, well-controlled and cost-effective models allowing unbiased high-throughput studies are needed. The nematode C. elegans is a genetically tractable model, ideally suited for mechanistic and causative studies of host-microbiome and microbe-microbe interactions shaping host physiology and metabolism. Aims: 1) Establish an experimental microbiome in C. elegans based on strains from the human microbiome associated with health, disease and ageing 2) Generate fluorescent labelled bacterial strains and perform real-time imaging of gut colonisation 3) Characterise the effects of the experimental microbiome on the microbiome-gut-brain axis during ageing The experimental microbiome in C. elegans will be an important contribution to the field, complementing existing models. It will allow me to establish important collaborations, form a basis for my future research and address one of the most important questions of modern biology: the effects of the microbiome on host physiology.
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Grant Details
Amount Awarded | 99905 |
Applicant Surname | Ezcurra |
Approval Committee | Science Seeds Advisory Panel |
Award Date | 2018-09-06T00:00:00+00:00 |
Financial Year | 2017/18 |
Grant Programme: Title | Seed Award in Science |
Internal ID | 213954/Z/18/Z |
Lead Applicant | Dr Marina Ezcurra |
Partnership Value | 99905 |
Planned Dates: End Date | 2022-01-03T00:00:00+00:00 |
Planned Dates: Start Date | 2019-04-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |