The proteomic architectures of apicomplexan cells: the molecular complexity of pathogens revealed (360G-Wellcome-214298_Z_18_Z)
Apicomplexan parasites represent highly adapted eukaryotic pathogens that have evolved to exploit multiple human and animal niches causing widespread disease and food deprivation. Key to their success as parasites are novel organelles and structures adapted for invasion and mediation of interactions with their hosts. They have also reprogrammed canonical cell compartments with modified metabolic capacities and regulatory control. An overwhelming obstacle to understanding the biology of these parasites and their mechanisms of pathogenesis is that much of the parasite proteome is unique in Apicomplexa, with most proteins of unknown location or function. My group uses a novel method for whole-cell spatial proteomics in apicomplexan parasite-host systems that simultaneously captures the locations and associations of thousands of parasites proteins. This provides intimate and thorough illumination of the architecture and adaptations of these devastating pathogens at an organelle-, sub-compartment- and protein complex-level. We will define the commonalities and differences between major pathogen groups Plasmodium and Toxoplasma, the destinations of proteins they export into their hosts, and the spatial dynamics of their proteomes during infection developmental cycles. This comprehensive knowledge will enable molecular mechanistic understanding of these pathogens that is essential for effective design and implementation of disease management and prevention strategies.
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Grant Details
Amount Awarded | 1687461 |
Applicant Surname | Waller |
Approval Committee | Science Interview Panel |
Award Date | 2018-11-27T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 214298/Z/18/Z |
Lead Applicant | Prof Ross Waller |
Partnership Value | 1687461 |
Planned Dates: End Date | 2024-06-24T00:00:00+00:00 |
Planned Dates: Start Date | 2019-03-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |