The proteomic architectures of apicomplexan cells: the molecular complexity of pathogens revealed (360G-Wellcome-214298_Z_18_Z)

£1,687,461

Apicomplexan parasites represent highly adapted eukaryotic pathogens that have evolved to exploit multiple human and animal niches causing widespread disease and food deprivation. Key to their success as parasites are novel organelles and structures adapted for invasion and mediation of interactions with their hosts. They have also reprogrammed canonical cell compartments with modified metabolic capacities and regulatory control. An overwhelming obstacle to understanding the biology of these parasites and their mechanisms of pathogenesis is that much of the parasite proteome is unique in Apicomplexa, with most proteins of unknown location or function. My group uses a novel method for whole-cell spatial proteomics in apicomplexan parasite-host systems that simultaneously captures the locations and associations of thousands of parasites proteins. This provides intimate and thorough illumination of the architecture and adaptations of these devastating pathogens at an organelle-, sub-compartment- and protein complex-level. We will define the commonalities and differences between major pathogen groups Plasmodium and Toxoplasma, the destinations of proteins they export into their hosts, and the spatial dynamics of their proteomes during infection developmental cycles. This comprehensive knowledge will enable molecular mechanistic understanding of these pathogens that is essential for effective design and implementation of disease management and prevention strategies.

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Grant Details

Amount Awarded 1687461
Applicant Surname Waller
Approval Committee Science Interview Panel
Award Date 2018-11-27T00:00:00+00:00
Financial Year 2018/19
Grant Programme: Title Investigator Award in Science
Internal ID 214298/Z/18/Z
Lead Applicant Prof Ross Waller
Partnership Value 1687461
Planned Dates: End Date 2024-06-24T00:00:00+00:00
Planned Dates: Start Date 2019-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England