Common Variant Genetics of Autism and Autistic Traits (GWAS) Consortium (360G-Wellcome-214322_Z_18_Z)
Autism is a life-long developmental condition with a prevalence of approximately 1%, and heritability estimates of between 64-92%. It is polygenic, with variants across the frequency spectrum (from rare to common) contributing to risk. Considerable progress has been made in identifying rare variants in autism, but the largest genome-wide association study (GWAS) of autism (18,000 cases, 28,000 controls) identified only five loci associated with autism, compared to 179 in schizophrenia (40,000 cases, 65,000 controls). Polygenic scores account for 2.45% of the variance in autism, despite 30-50% of the variance in risk for autism being attributable to common variants, suggesting many more common variants remain to be found. Additionally, autistic traits are normally distributed in the general population, but there is no well-powered GWAS of autistic traits. The proposed research aims to accelerate the discovery of common, low frequency, and copy number variants in autism and autistic traits. Specifically, we will: (1) Establish a UK-wide Autism Biobank (N = 10,000 cases), with links to electronic health records and who can be recalled by genotype; (2) Conduct a GWAS of autism in 100K cases from around the world; and (3) Conduct a GWAS of autistic traits in the population in 250K individuals
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Grant Details
Amount Awarded | 3182054 |
Applicant Surname | Baron-Cohen |
Approval Committee | Science Interview Panel |
Award Date | 2018-11-27T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Collaborative Award in Science |
Internal ID | 214322/Z/18/Z |
Lead Applicant | Prof Simon Baron-Cohen |
Other Applicant(s) | Prof Daniel Geschwind, Prof David Rowitch, Prof Matthew Hurles |
Partnership Value | 3182054 |
Planned Dates: End Date | 2025-01-15T00:00:00+00:00 |
Planned Dates: Start Date | 2019-01-15T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |