Metabolic Dysregulation in Skeletal muscle and Adipose Following allogeneic haematopoietic stem cell transplant in children, teenagers and young adults (360G-Wellcome-215859_Z_19_Z)

Disease and under-nutrition in children can exert profound effects on growth and development and have adverse later effects that continue into adulthood. The treatments used in the management of disease can also exert effects which although curative have immediate short-term effects on nutritional state and metabolism but also persist into later life with increased morbidity and mortality. At the heart of many of these disease and treatment-induced changes in metabolic regulation and control are attributable to a limited number of cellular processes relating to cellular bioenergetics, redox/antioxidant state and inflammation. Within this paradigm, we seek support to develop a program of work to better understand how these processes contribute to an overt example of accelerated ageing/metabolic dysregulation seen in Children, teenagers and young adults(CTYA) surviving Acute Lymphoblastic Leukaemia(ALL) treated with allogeneic haematopoietic stem cell transplantation(HSCT) and intervene through targeted nutritional and exercise interventions. Our key goals are to i) build a multi-disciplinary team with complimentary capabilities to explore and explain the clinical and biological consequences of HSCT from the molecular to the whole body level, ii) synthesise the available evidence and case-identification, and iii) develop methodology, to work together to construct a high quality research program application for follow-on funding.