Generation Scotland:NextGenScot (360G-Wellcome-216767_Z_19_Z)

Generation Scotland:NextGenScot (NextGenScot) builds upon the proven success and research value of Generation Scotland (GS). We will extend the reach and relevance of GS through recruitment of additional members and younger relatives of current participants. Our vision is to transform GS from a cross- sectional, adult-only study into a longitudinal, multi-generational, life- course study that can address how genetic factors and environmental exposures influence disease risk, resilience and outcome. As for GS, we will: \- engage with participants to shape the study objectives and seek broad consent for medically-relevant academic and commercial research, \- seek consent to recontact for participation in follow-on enhancement studies, our proven mechanism to enrich the baseline data, \- actively facilitate hypothesis and data-driven science by research users, openly sharing our research findings. NextGenScot expands GS to create an enhanced resource of scale (n=40,000), depth and rich annotation through: \- self-report and serial remote data capture of health and lifestyle information; \- e-HR linkage (from ‘birth-to- death’, updated annually); and \- biological samples (collected at recruitment and longitudinally). NextGenScot would be the UK’s largest multi-generation study of clinical, biochemical, genetic, epigenetic and environmental health determinants, allowing estimation and determination of transgenerational effects (social, environmental and genetic) on disease risk and resilience.