DNA methylation of different brain cell types in Parkinson’s disease (360G-Wellcome-217561_Z_19_Z)
Parkinson’s disease is an increasing global concern, affecting one in twenty people by age 85 and costing the NHS more than £1 billion/year. The underlying mechanisms are still almost completely unknown and there are no drugs that can cure the disease. In addition to traditional genetics, recent work in Parkinson’s has focussed on epigenetic variation, in particular DNA methylation in the brain. However, even though different brain cell types are affected by Parkinson’s in different ways, all previous work has only considered bulk brain tissue consisting of a mixture of cell types. For the first time, this project will determine the DNA methylation profile in individual cell types of the prefrontal cortex in both people with Parkinson’s and matched controls. In particular, this will include separate analysis of neurons, oligodendrocytes and other glial cells. This will generate pilot data that will lead to several large ( > £1M) follow-up grant applications, including not only studies of DNA methylation, but single-cell-type investigations of other epigenetic marks such as histone modifications and non-coding RNAs. The hope is that this approach will lead to a step change in the mechanistic understanding of Parkinson’s disease, and produce a host of new potential drug targets.
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Grant Details
Amount Awarded | 99458 |
Applicant Surname | Migdalska-Richards |
Approval Committee | Science Seeds Advisory Panel |
Award Date | 2019-04-11T00:00:00+00:00 |
Financial Year | 2018/19 |
Grant Programme: Title | Seed Award in Science |
Internal ID | 217561/Z/19/Z |
Lead Applicant | Dr Anna Migdalska-Richards |
Partnership Value | 99458 |
Planned Dates: End Date | 2025-03-29T00:00:00+00:00 |
Planned Dates: Start Date | 2021-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South West |