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Investigating the impact of seizures on newborn brain (360G-Wellcome-219610_Z_19_Z)

Seizures are a common manifestation of brain injury in newborn infants. Controversies still exist over whether seizures may themselves cause further damage to the developing brain, when to treat them, what drugs to use and how to improve detection. There is an urgent need for a better understanding of the pathophysiological changes to improve our management strategies. My key goal is to assess the impact of seizures on the newborn brain. I propose to use a new optical platform (combined broadband near-infrared spectroscopy and diffusion correlation spectroscopy) for a comprehensive real-time assessment of cerebral metabolism (using oxCCO and CMRO2), haemodynamics (using CBF and CBV) and oxygenation (using TOI) together with video-electroencephalography(EEG) at the cot-side to investigate seizure-induced changes inside brain. I aim to deliver a translational and clinical strategy to investigate these changes in healthy brains of an animal model and in a cohort of babies in neonatal intensive care who developed seizures after brain injury. I will further investigate the impact of phenobarbitone on brain metabolism and haemodynamics. Short and long-term impacts will be assessed with neuroimaging and neurodevelopmental outcome data. These findings will improve our understanding and will support an evidence-based approach for the management of neonatal seizures.


05 Dec 2019

Grant details
Amount Awarded 755905
Applicant Surname Mitra
Approval Committee Clinical Interview Committee
Award Date 2019-12-05T00:00:00+00:00
Financial Year 2019/20
Grant Programme: Title Clinical Research Career Development Fellowship
Internal ID 219610/Z/19/Z
Lead Applicant Dr Subhabrata Mitra
Planned Dates: End Date 2024-07-31T00:00:00+00:00
Planned Dates: Start Date 2020-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Anna David
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