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The Impact of Pneumococcal and Malaria Vaccines on Bacterial Resistance, Febrile Illness and Antibiotic Usage in Young Children In Malawi (360G-Wellcome-219900_Z_19_Z)

Across much of sub-Saharan Africa, pneumococcal disease (otitis media and pneumonia) and malaria are leading causes febrile illness, and therefore drivers of both appropriate and inappropriate antibiotic use. Prevention through vaccination has the potential to influence antimicrobial resistance (AMR) both directly and indirectly. We are in a unique position to leverage two large funded cluster-randomised vaccine evaluations in Malawi: 13-valent pneumococcal conjugate vaccine (PCV13) schedule change (3+0 to 2+1; extending immunity and potentially herd protection); and RTS,S malaria vaccine introduction. We will ask what are the direct and indirect selective effects of pneumococcal and malaria vaccines on antibiotic resistance, febrile illness and antibiotic usage in young children in Malawi? We will determine whether in children S. pneumoniae carriage isolates; the upper respiratory tract resistome; and stool carriage of extended spectrum beta-lactamase (ESBL) E. coli or Klebsiella. We will assess whether the pneumococcal or malaria vaccines alter the frequency of febrile illness and antibiotic use in children

£764,996

30 Nov 2019

Grant details
Amount Awarded 764996
Applicant Surname Heyderman
Approval Committee Vaccines Advisory Panel
Award Date 2019-11-30T00:00:00+00:00
Financial Year 2019/20
Grant Programme: Title Impact of vaccines on antimicrobial resistance
Internal ID 219900/Z/19/Z
Lead Applicant Prof Robert Heyderman
Other Applicant(s) Dr Jose Lourenco, Prof Sunetra Gupta, Mr Todd Swarthout, Prof Ken Maleta, Prof Neil French, Dr Jennifer Cornick, Prof Stephen Bentley
Planned Dates: End Date 2021-12-31T00:00:00+00:00
Planned Dates: Start Date 2019-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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