Mechanisms and roles of transmissible RNA (360G-Wellcome-220180_Z_20_Z)

£1,393,480

Protein coding and non-coding RNA can spread between cells and tissues of an organism. RNA mobility between organisms has been documented within and among different kingdoms of life including fungi, plants and animals. However, the underlying mechanisms and roles of such transmissible RNA are poorly understood. Our recent studies demonstrated that honeybees share biologically active RNA among members of the hive through secretion and ingestion of worker and royal jellies. The jellies harbor naturally occurring exogenous (e.g. viral) and endogenous RNA. These findings suggest that RNA transfer plays a role in social immunity and signaling between honeybees. Therefore, the key goals of this proposal are: to establish a metabolic RNA labeling system in honeybees; and to apply this system to study natural RNA transfer-mediated antiviral immunity and impacts on the physiology of recipient bees. To achieve these goals, I will combine RNA biology techniques and imaging with high-throughput sequencing to establish a functional transmissible RNA pathway in honeybees. This project will provide knowledge and tools that will enable studying the biology of RNA flow in other organisms, including humans, in diverse biological aspects; hence, will ultimately contribute to the development of RNA-based applications to promote health and disease control.

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Grant Details

Amount Awarded 1393480
Applicant Surname Maori
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2020-03-04T00:00:00+00:00
Financial Year 2019/20
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 220180/Z/20/Z
Lead Applicant Dr Eyal Maori
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 1393480
Planned Dates: End Date 2026-04-14T00:00:00+00:00
Planned Dates: Start Date 2021-04-15T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Gerard Evan