Development of in-vivo 19F Clinical MR imaging Using a Novel 19F/1H Coil in Combination with an Intravenous Perfluorocarbon (ABL-101) (360G-Wellcome-222695_Z_21_Z)
The main deliverable will be proof of principle for 19F MR imaging in humans using ABL-101, a perfluorocarbon (PFC) emulsion. Aurum Biosciences Ltd (Aurum), a spin-out company from the University of Glasgow (UoG) and NHS Greater Glasgow & Clyde (GGC) is developing ABL-101 for diagnosis and treatment of acute ischaemic stroke. Development of 19F MRI would allow ABL-101 to be used as a diagnostic imaging agent for inflammation. ABL-101 has been tested in Phase 1 and 2 clinical trials. It has also received MHRA approval for Phase 2 studies in acute stroke patients funded by the Wellcome Trust, providing a unique opportunity to also explore 19F MRI and significantly saving development costs and time. Funding will also result in validation of the novel 19F/1H coil which has been built by the UoG for clinical research use. Currently there are no CE marked coils for 19F MRI and this funding will be the first step towards a CE marked coil for clinical use. We will also optimise 19F MRI pulse sequences and scanning protocols for 19F MRI in a clinical 3T scanner. Ultimately, we aim to commercialise ABL-101 in conjunction with 19F/1H RF coil and software for 19F clinical inflammatory imaging.
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Grant Details
| Amount Awarded | 317317 |
| Applicant Surname | Fullerton |
| Approval Committee | Innovator Awards Advisory Group |
| Award Date | 2021-02-04T00:00:00+00:00 |
| Financial Year | 2020/21 |
| Grant Programme: Title | Innovator Award |
| Has the grant transferred? | No |
| Internal ID | 222695/Z/21/Z |
| Lead Applicant | Dr Natasha E Fullerton |
| Other Applicant(s) | Prof David Andrew Porter, Prof Keith Muir, Dr Alex McConnachie, Dr Shajan Gunamony |
| Planned Dates: End Date | 2026-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2021-08-01T00:00:00+00:00 |
| Recipient Org: City | Glasgow |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 317317 |