The role of capillary pericytes and LRP-1 in Parkinson's disease and dementia (360G-Wellcome-224632_Z_21_Z)
I previously showed that in Alzheimer's disease (AD) amyloid beta constricts brain capillaries via signalling to pericytes. I now wish to investigate: (1) Parkinson's disease (PD) / Lewy Body Dementia (DLB), where alpha-synuclein evokes ROS production and hypothesise that endothelin will be released (as observed in AD) and evoke pericyte-mediated capillary constriction to decrease cerebral blood flow. (2) The role of APOE receptor LRP-1 in regulating increased tau phosphorylation in AD. LRP-1 is a master regulator of tau uptake/spread and highly expressed on pericytes. In AD model mice, pericyte deficiency leads to tau pathology and early neuronal loss. Thus, pericyte LRP-1 may play an important role in clearing/processing tau in the setting of amyloid pathology. I will examine whether AD-like tau pathology develops in an APP knock-in AD/pericyte-LRP-1 deficient mouse model. (3) The effect of Covid-19 on live human pericytes and capillaries.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 644817 |
| Applicant Surname | Nortley |
| Approval Committee | Clinical Interview Committee |
| Award Date | 2021-11-16T00:00:00+00:00 |
| Financial Year | 2021/22 |
| Grant Programme: Title | Clinical Research Career Development Fellowship - Stage 1 |
| Has the grant transferred? | No |
| Internal ID | 224632/Z/21/Z |
| Lead Applicant | Dr Ross R Nortley |
| Planned Dates: End Date | 2026-10-27T00:00:00+00:00 |
| Planned Dates: Start Date | 2022-03-28T00:00:00+00:00 |
| Recipient Org: City | London |
| Recipient Org: Country | United Kingdom |
| Region | London |
| Research conducted at multiple locations? | No |
| Sponsor(s) | Prof David Attwell |
| Total amount including partnership funding | 644817 |