How does strabismus in childhood affect depression and anxiety later in life? (360G-Wellcome-227484_Z_23_Z)

Background Mental health is a major cause of disability. Some people with squint and related conditions are more likely to be affected. Most studies that have looked at squints or related nervous system and eye related problems do not have enough information to assess mental health outcomes. Large studies, such as Children of the 90’s, Generation Rotterdam, RAINE study (Western Australia) and UK Biobank, hold lots of eye, genetic and mental health information that can be used to measure the effect of squint on mental health. Research Approach \- Use eye and mental health information from large studies to see how and why squint affects mental health \- Use a combination of observational and genetic information from large studies (with multiple eye related measures and mental health records) to measure how much squint affects mental health \- Interview people with squint to see how squint and patient’s hospital care affected their mental health Impact \- Understand how squint and related conditions affect mental health \- Think of new ways to reduce the risk of poor mental health for people with squint \- Help the NHS and its funders make policy for how to treat people with squint.