Genetic and environmental factors conferring susceptibility to adverse respiratory impacts of air pollution (360G-Wellcome-228298_Z_23_Z)

Air pollution affects over 90% of the global population and is associated with several health impacts. Lung function, a predictor of all-cause mortality, is also affected by air pollution exposure. Therefore, the detrimental effects of air pollution need to be mitigated to reduce the lung disease burden and mortality. Under the hypothesis that pollutants can initiate oxidative stress, we aim to investigate antioxidant properties to attenuate the adverse respiratory effects of air pollution. To do this, we will explore antioxidant gene variability, antioxidant diets, and other genetic variants that may influence the effects of air pollution on lung function in the European population of the UK Biobank. In addition to antioxidant diets, other lifestyle choices, such as physical activity, will be considered. The results of this project will inform policymakers and contribute to the prevention of poor lung function and reduction of mortality worldwide, particularly in communities at a higher risk of air pollution exposure.