Deconvoluting causes of heart failure risk and progression using human genetics (360G-Wellcome-316966_Z_24_Z)
Heart failure is a serious medical condition in which the heart is unable to pump enough blood to meet the needs of the body. It can be caused by a variety of factors, including high blood pressure, diabetes, and obesity. Once a person develops heart failure, they are at higher risk of experiencing bad outcomes, such as admission to hospital or death (disease progression). This project will use human genetics and data collected from people over many years to better understand heart failure, with a focus on the role of adiposity. Using genetic data from large populations (the HERMES consortium, UK BioBank, and the Avon Longitudinal Study of Parents and Children - ALSPAC), I hope to identify specific biological pathways that link excess fat to the development of heart failure and disease progression thereafter. This information could potentially be used to identify new drug targets or treatments to prevent or slow the progression of heart failure, ultimately improving outcomes for individuals with this condition.
Where is this data from?
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Grant Details
| Region | South West |
| Award Date | 2024-09-30T00:00:00+00:00 |
| Sponsor(s) | Dr Lavinia Paternoster |
| Internal ID | 316966/Z/24/Z |
| Planned Dates: End Date | 2028-01-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2025-01-31T00:00:00+00:00 |
| Amount Awarded |
0
|
| Financial Year | 2023/24 |
| Lead Applicant | Dr Nicholas Sunderland |
| Grant Programme: Title | PhD Studentship for Health Professionals |
| Applicant Surname | Sunderland |
| Approval Committee | Discretionary Award decision meeting |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | Bristol |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 0 |