Co-circulation dynamics of dengue and Zika virus in East Africa and Mexico and its impact on cross-reactive immunity (360G-Wellcome-317324_Z_24_Z)

The emergence of Zika virus (ZIKV) in the Americas foreshadowed recent unprecedented dengue virus (DENV) outbreaks inhyperendemic regions that show yearly incremental trends. Despite the clinical risks associated with DENV serotype 1-4 co-circulation and Zika infection, there are important gaps in our understanding of transmission dynamics of these closely related flaviviruses in high-risk regions such as East Africa and North America. In addition, correlates of protection and pathogenesis, particularly in the context of ZIKV and DENV cross-reactive immunity, are poorly understood. The overarching goals of this research program are to gather serological and genetic evidence on the co-circulation of DENV and ZIKV to enhance our understanding of how they spread in understudied regions of Uganda and Mexico and neighboring regions; (2) identify differences in trans-continental drivers that will help predict future spread; (3) assess immunity and pathogenesis associated with exposure histories; and (4) to inform public policy decision makers on spatiotemporal transmission dynamics to direct mitigation strategies. This program will take a multi-disciplinary approach engaging epidemiologists, immunologists, virologists, entomologists, veterinarians, promoters of capacity building and public health professionals from leading universities and public health institutions from participant countries.