Diastolic blood pressure across the life course, risk factors, and consequences (360G-Wellcome-319377_Z_24_Z)
Increasing evidence suggests that variability of blood pressure (BP), specifically systolic blood pressure (SBP), is a risk factor for cardiovascular events, and stroke, and these all cause mortality. However, little is known about the impacts of diastolic blood pressure (DBP) variation within-people on cardio- and cerebrovascular outcomes, or how this variation is linked to poor cardiovascular and cerebrovascular function. Therefore, the primary aim of this study is to understand the effects of variability of DBP on cardiovascular and cerebrovascular function and outcomes. While most studies investigate the effects of between-person variability of DBP on health outcomes, we will investigate the effects of within-individual variability of DBP on brain white matter hyperintensities; an indicator of cerebrovascular health, and coronary artery calcium (CAC), which assesses the severity of plaque buildup in the arteries.1 Additionally, we will explore how beat-to- beat , and 24-hour DBP variability relate to white matter hyperintensities and cerebrovascular CO2 reactivity. Furthermore, we will investigate the independent effects of DBP and pulse pressure (PP) on cardiovascular endpoints using multivariable Mendelian randomization. Key words: DBP, cerebrovascular, cardiovascular, Mendelian randomization
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Grant Details
| Region | South West |
| Award Date | 2024-10-01T00:00:00+00:00 |
| Sponsor(s) | Prof Abigail Fraser |
| Internal ID | 319377/Z/24/Z |
| Planned Dates: End Date | 2027-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2024-10-01T00:00:00+00:00 |
| Amount Awarded |
0
|
| Financial Year | 2024/25 |
| Lead Applicant | Miss Vandana Venkat |
| Grant Programme: Title | PhD Studentship (Basic) |
| Applicant Surname | Venkat |
| Approval Committee | Discretionary Award decision meeting |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | Bristol |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 0 |